The globus pallidus pars interna in goal‐oriented and routine behaviors: Resolving a long‐standing paradox
نویسندگان
چکیده
منابع مشابه
Impaired reaching and grasping after focal inactivation of globus pallidus pars interna in the monkey.
The purpose of this study was to test the hypothesis that the basal ganglia output from globus pallidus pars interna (GPi) contributes to inhibition of competing motor patterns to prevent them from interfering with a volitional movement. To test this hypothesis, the kinematics of a natural reach, grasp, and retrieval task were measured in the monkey before and after focal inactivation in GPi wi...
متن کاملPreliminary evidence for human globus pallidus pars interna neurons signaling reward and sensory stimuli
The globus pallidus pars interna (GPi) is a component of the basal ganglia, a network of subcortical nuclei that process motor, associative, and limbic information. While non-human primate studies have suggested a role for the GPi in non-motor functions, there have been no single-unit studies of non-motor electrophysiological behavior of human GPi neurons. We therefore sought to extend these fi...
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A BSTRACT Background Increased neuronal activity in the subthalamic nucleus and the pars interna of the globus pallidus is thought to account for motor dysfunction in patients with Parkinson’s disease. Although creating lesions in these structures improves motor function in monkeys with induced parkinsonism and patients with Parkinson’s disease, such lesions are associated with neurologic defic...
متن کاملDeep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease.
BACKGROUND Increased neuronal activity in the subthalamic nucleus and the pars interna of the globus pallidus is thought to account for motor dysfunction in patients with Parkinson's disease. Although creating lesions in these structures improves motor function in monkeys with induced parkinsonism and patients with Parkinson's disease, such lesions are associated with neurologic deficits, parti...
متن کاملGlobus Pallidus Interna Deep Brain Stimulation for Chorea-Acanthocytosis
Chorea-acanthocytosis (ChAc) is a rare hereditary disorder characterized by involuntary choreiform movements and erythrocytic acanthocytosis. Pharmacotherapy for control of involuntary movements has generally been of limited benefit. Deep brain stimulation (DBS) has recently been used for treatment of some refractory cases of ChAc. We report here on the effect of bilateral high-frequency DBS of...
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ژورنال
عنوان ژورنال: Movement Disorders
سال: 2016
ISSN: 0885-3185,1531-8257
DOI: 10.1002/mds.26542